GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs13191362 | 1 | rs1333963 | chr6:163192571 | PACRG | chr6:163148164-163736523:+ | 0.21 | 3.43 | 0.000632 | Body mass index |
| BRCA | cis | rs4803468 | 1 | rs13344563 | chr19:41945904 | B3GNT8 | chr19:41931265-41934635:- | 0.2 | 6 | 2.74E-9 | Height |
| BRCA | cis | rs13358904 | 1 | rs13358904 | chr5:111602713 | FLJ11235 | chr5:111755280-111756673:+ | 0.13 | 3.65 | 0.000279 | Suicide ideation score in major depressive disorder |
| BRCA | cis | rs10043228 | 1 | rs13362043 | chr5:115596262 | COMMD10 | chr5:115420727-115628978:+ | 0.22 | 4.58 | 5.21E-6 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs6666258 | 1 | rs13376333 | chr1:154814353 | RAG1AP1 | chr1:155108288-155357080:+ | -0.12 | -3.95 | 8.44E-5 | Atrial fibrillation |
| BRCA | cis | rs1577917 | 1 | rs1337844 | chr6:86677273 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -17.75 | 6.06E-62 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs1337850 | chr6:86729103 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.65 | 2.04E-67 | Response to antipsychotic treatment |
| BRCA | cis | rs6741892 | 1 | rs13383762 | chr2:38907001 | GALM | chr2:38893052-38961908:+ | 0.34 | 6.08 | 1.64E-9 | 5-HTT brain serotonin transporter levels |
| BRCA | cis | rs9309473 | 1 | rs13384952 | chr2:73723959 | ALMS1P | chr2:73872046-73912692:+ | -0.21 | -4.77 | 2.13E-6 | Metabolite levels |
| BRCA | cis | rs13385191 | 1 | rs13385191 | chr2:20888265 | C2orf43 | chr2:20883803-21022827:- | -0.54 | -11.64 | 1.39E-29 | Prostate cancer |
| BRCA | cis | rs13387221 | 1 | rs13387221 | chr2:44135314 | LRPPRC | chr2:44113363-44223144:- | -0.13 | -3.93 | 9.17E-5 | Intelligence (childhood) |
| BRCA | cis | rs12468226 | 1 | rs13389798 | chr2:203213093 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.55 | 0.000401 | Urate levels |
| BRCA | cis | rs6738490 | 1 | rs13391356 | chr2:234170369 | SAG | chr2:234216309-234255701:+ | 0.13 | 4.09 | 4.55E-5 | Crohn's disease |
| BRCA | cis | rs13393800 | 1 | rs13393692 | chr2:233442016 | EIF4E2 | chr2:233415357-233448349:+ | -0.2 | -4.54 | 6.27E-6 | Height |
| BRCA | cis | rs13393800 | 1 | rs13393692 | chr2:233442016 | TIGD1 | chr2:233412779-233415226:- | -0.14 | -3.68 | 0.000247 | Height |